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NADPH oxidase is one of the major sources of intracellular ROS, which can activate a series of signaling pathways
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There isnt any scientific evidence that taking berberine after a meal wont be effectivebut taking it before or with a meal is generally recommended because of the way its metabolized, and it may help lessen GI side effects
Some report improved sleep quality or subtle increases in energy, though these could reflect placebo effects
Zhu, Y., Xia, T., Chen, D
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